Evaluating Differential Privacy Against Membership Inference in Federated Learning: Insights from the NIST Genomics Red Team Challenge

arXiv:2603.28942v3 Announce Type: replace Abstract: The pervasive deployment of deep learning models across critical domains has concurrently intensified privacy concerns due to their inherent propensity for data memorization. While Membership Inference Attacks (MIAs) serve as the gold standard for auditing these privacy vulnerabilities, conventional MIA paradigms are increasingly constrained by the prohibitive computational costs of shadow model training and a precipitous performance degradation under low False Positive Rate constraints. To overcome these challenges, we introduce a novel perspective by leveraging the principles of model reprogramming as an active signal amplifier for privacy leakage. Building upon this insight, we present \texttt{ReproMIA}, a unified and efficient proactive framework for membership inference. We rigorously substantiate, both theoretically and empirically, how our methodology proactively induces and magnifies latent privacy footprints embedded within the model's representations. We provide specialized instantiations of \texttt{ReproMIA} across diverse architectural paradigms, including LLMs, Diffusion Models, and Classification Models. Comprehensive experimental…